Laboratory of Tumor Immunology
Our research focuses on understanding the transcriptional regulation of pro-inflammatory and anti-apoptotic genes. This is important in metastatic cancer cells but also in activated white blood cells and chronic inflammatory disorders. Our ongoing studies focus on two principal issues: 1) What are the mechanisms regulating expression of pro-inflammatory and pro-angiogenic chemokines in cancer cells and activated human leukocytes? 2) What are the molecular mechanisms regulating transcription of anti-inflammatory genes in human leukocytes? To answer these questions, we use novel and standard approaches of immunology, molecular and cell biology, and biochemistry.
This research has been enriched tremendously by the diligent and creative work of many graduate and undergraduate students, who after graduating from SJU, assumed research positions at Harvard Medical School, Columbia Medical School, University of Chicago, and other premier research institutions.
In addition, our work has been greatly advanced by collaborations with our colleagues from Albert Einstein College of Medicine, Feinstein Institute for Medical Research, Harvard Medical School, and Stony Brook University Medical School.
This research has been published in over 60 research articles and funded by the National Institutes of Health.
National Institute of Child and Human Development
National Institute of General Medical Sciences
National Institute of Allergy and Infectious Diseases
National Cancer Institute
Vancurova Lab, 2014
Former PhD Students
Chandra Ghosh, PhD, 2009: Harvard
Ashish Juvekar, PhD, 2010; Harvard
Ram Ramaswami, PhD Subrata Manna, PhD
2011; Columbia 2013; AECOM
Undergraduate Immunology, BIO-3460
Immune System in Human Disease, BIO-2290
Graduate Immunology, BIO-250